Functional ability in knee osteoarthritis: role of neuropathic pain and central sensitization

Abstract Background Pain in osteoarthritis (OA) has been attributed traditionally to local tissue injury causing ‘nociceptive pain’. However, recent studies suggest that neuropathic and central sensitization mechanisms may contribute the pain experience. relationship between these physical function not thoroughly addressed. This study aimed assess association of with knee OA. Results Participants a positive inventory score (CSI) (≥ 40) had decreased total Knee Osteoarthritis Outcome Score (KOOS) its subscales ( p < 0.001), longer timed up go test time = 0.002) higher PainDETECT questionnaire (PD-Q) visual analogue scale 0.001, 0.026 respectively). The severity Kellgren-Lawrence grading (KL) depressive anxiety symptoms 0.001) increased severity. In addition, participants high PD-Q 19) KOOS 0.001). Moreover, we found CSI score, KL were significantly predicted 0.046, 0.007, Regarding predictors, multivariate linear regression analysis revealed pressure threshold at right elbow 0.005, addition P associated while Hospital Anxiety Depression Scale not. Conclusion OA patients significant reported pain, more functional impairment, than without pain. Additionally, presence predictors for ability.